hcv in intravenous drug users
نویسندگان
چکیده
background: hepatitis c (hcv) is increasing worldwide including iran. hcv is more prevalent among intravenous drug abusers (idu), especially if imprisoned, mostly due to needle sharing. we determined the rate of hcv seropositivity among idu prisoners and compared it with those of non prisoners. materials and methods: a cross-sectional survey was done on consenting idu inhabiting two prisons and attending three rehabilitation centers in tehran, iran. a questionnaire was completed for each subject and 5ml blood drawn. the samples were kept at 2-8â°c until the sera were separated and stored at -70â°c. hcv ab (elisa 1, third generation, dia. pro, italy) with a sensitivity and specificity of 98% was checked by a single technician. chi-square, fisher's exact test and multivariable analysis were used where appropriate. results: four-hundred and sixty seven subjects [346 (74.1%) prisoners; 425 (91%) male] were enrolled. overall 66% tested positive for hcv ab [287 male (67.5%), 21 female (50%), p‹0.02]. hcv seropositivity was higher among prisoners (78.3% vs. 30.6%, p‹0.001) and older idu (76.9% vs. 62.9%, p=0.002). multivariable analysis showed association between hcv seropositivity and imprisonment (or= 9.32, 95%ci: 5.60-15.51), sharing syringes (or=2.00, 95%ci: 1.27-3.17), duration of intravenous drug use annually (or=1.16, 95%ci: 1.08-1.24) and male sex (or=4.18, 95%ci: 2.02- 8.67). conclusions: hcv is rather common among idu prisoners. imprisonment is an independent risk factor. the infected idu going back to the community may be an important source of hcv. taking effective strategies (high risk group education, provision of sterile syringes, identification and treatment of infected idu) to reduce the risk of this public health problem is needed urgently.
منابع مشابه
CCR5 Haplotypes Influence HCV Serostatus in Caucasian Intravenous Drug Users
BACKGROUND Up to 90% HIV-1 positive intravenous drug users (IDUs) are co-infected with HCV. Although best recognized for its function as a major co-receptor for cell entry of HIV, CC chemokine receptor 5 (CCR5) has also been implicated in the pathogenesis of HCV infection. Here, we investigated whether CCR5 haplotypes influence HIV-1 and HCV seropositivity among 373 Caucasian IDUs from Estonia....
متن کاملHIV and HCV Transmission Among Intravenous Drug Users
This paper examines the evidence for harm reduction policies on HIV and HCV transmission, evaluating the benefit to drug users and the community. Surveys show that HIV is primarily transmitted through unsafe sexual activity, while HCV is almost exclusively transmitted by unsafe drug injecting. A review of studies on NSPs and their effectiveness in preventing transmission of HCV and HIV shows th...
متن کاملThe Molecular Epidemiological Study of HCV Subtypes among Intravenous Drug Users and Non-Injection Drug Users in China
BACKGROUND More than half of intravenous drug users (IDUs) in China suffer from the Hepatitis C virus (HCV). The virus is also more prevalent in non-injection drug users (NIDUs) than in the general population. However, not much is known about HCV subtype distribution in these populations. METHODS Our research team conducted a cross-sectional study in four provinces in China. We sampled 825 ID...
متن کاملAlarming increase in tuberculosis and hepatitis C virus (HCV) among HIV infected intravenous drug users
INTRODUCTION In the last years, we observed an alarming increase in the number of newly diagnosed HIV infected intravenous drug users (IDUs) co-infected with hepatitis viruses or with severe bacterial infections. The aim of our study was to assess the incidence, the demographic and clinical characteristics of IDUs diagnosed with HIV, HCV and tuberculosis (TB). MATERIALS AND METHODS Prospectiv...
متن کاملCo-infection with hepatitis C virus (HCV) in Estonian intravenous drug users HIV epidemic
Estonian concentrated HIV epidemic started in August 2000 when rare HIV-1 CRF06_cpx was introduced into the population of intravenous drug users (IDUs). The majority of these HIV-positive subjects are likely co-infected with HCV but the prevalence of HCV and its genotypes during HIV concentrated epidemic in Estonia is largely unknown. The Estonian HIV database collects clinical and laboratory d...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
گوارشجلد ۱۰، شماره ۲، صفحات ۸۰-۰
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023